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Pulmonary disease burden in Hispanic and non‐Hispanic children with sickle cell disease
Author(s) -
Chen Laura,
Gong Jacqueline,
Matta Esther,
Morrone Kerry,
Manwani Deepa,
Rastogi Deepa,
De Aliva
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24883
Subject(s) - medicine , acute chest syndrome , pulmonary function testing , disease , asthma , vital capacity , sickle cell anemia , pediatrics , lung , lung function , diffusing capacity
Rationale Pulmonary complications are the leading cause of morbidity and mortality in sickle cell disease (SCD) patients. Research in SCD has predominantly been conducted on African‐Americans, and the disease burden of SCD in other races and ethnicities, including Hispanic patients, is not well characterized. Objective To compare pulmonary disease burden between Hispanic and non‐Hispanic ethnic groups among children with SCD. Methods In a retrospective chart review on 566 SCD patients followed at the Children's Hospital at Montefiore, NY, we compared the pulmonary disease burden and disease management in Hispanic patients to their non‐Hispanic counterparts. We also compared the contribution of demographic and clinical variables to acute chest syndrome (ACS), vaso‐occlusive crisis (VOC), and hospitalizations for SCD related complications between the two ethnic groups. Results Hispanic patients had a greater proportion of ACS, and had lower forced expiratory volume (FEV1), forced vital capacity, and vital capacity, compared to non‐Hispanics. Hispanic patients were more likely to be evaluated in pulmonary clinic and to be on inhaled corticosteroids, short‐acting β agonizts, and leukotriene receptor antagonists. In addition, Hispanic children were more likely to be on hydroxyurea, and receive exchange transfusions. However, the association of asthma with the proportion of ACS did not differ between Hispanics and non‐Hispanics. Conclusion Hispanic children with SCD had differences in their pulmonary function profile and received more pulmonary evaluations than non‐Hispanic children.