Premium
Urine gastrin‐releasing peptide in the first week correlates with bronchopulmonary dysplasia and post‐prematurity respiratory disease
Author(s) -
Voynow Judith A.,
Fisher Kimberley,
Sunday Mary E.,
Cotten Charles M.,
Hamvas Aaron,
HendricksMuñoz Karen D.,
Poindexter Brenda B.,
Pryhuber Gloria S.,
Ren Clement L.,
Ryan Rita M.,
Sharp Jack K.,
Young Sarah P.,
Zhang Haoyue,
Greenberg Rachel G.,
Herring Amy H.,
Davis Stephanie D.
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24665
Subject(s) - bronchopulmonary dysplasia , medicine , urine , odds ratio , gestational age , prospective cohort study , confidence interval , pediatrics , gastroenterology , physiology , pregnancy , genetics , biology
Bronchopulmonary dysplasia (BPD) is associated with post-prematurity respiratory disease (PRD) in survivors of extreme preterm birth. Identifying early biomarkers that correlate with later development of BPD and PRD may provide insights for intervention. In a preterm baboon model, elevated gastrin-releasing peptide (GRP) is associated with BPD, and GRP inhibition mitigates BPD occurrence.