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Social complexity negatively influences lung function in cystic fibrosis after transfer to adult care
Author(s) -
Crowley Erin M.,
Bosslet Gabriel T.,
Khan Babar,
Ciccarelli Mary,
Brown Cynthia D.
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24523
Subject(s) - medicine , interquartile range , cystic fibrosis , socioeconomic status , retrospective cohort study , lung function , population , demography , gerontology , pediatrics , lung , environmental health , sociology
Background Several nongenetic factors, such as socioeconomic status, environmental exposures, and adherence have been described to have an impact on outcomes in cystic fibrosis (CF). Objective To determine the effect of social complexity on the % predicted forced expiratory volume (ppFEV 1 ) before and after transfer to adult care among adolescents with CF. Methods Retrospective, single center, cohort study included all patients with CF who were transitioned into adult care between 2005 and 2015 at Indiana University. Social complexity (Bob's level of social support, [BLSS]) was collected at transfer. Linear mixed regression models assessed the relationship between ppFEV 1 decline over time and BLSS with other covariates. Results The median age of the patients (N = 133) at the time of transfer was 20 years (interquartile range: 19‐23). Overall, there was a decline in lung function over time in our population (ppFEV 1 at 24 months pretransfer 77 ± 20%, ppFEV 1 at 24 months, posttransfer 66 ± 24%; P < .001). The relationship between BLSS and ppFEV 1 became more negative over time, even after adjusting for other covariates. Conclusion Social complexity is strongly associated with lung function decline after transfer to adult care.