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Airway disease on chest computed tomography of preschool children with cystic fibrosis is associated with school‐age bronchiectasis
Author(s) -
Bouma Nynke R.,
Janssens Hettie M.,
Andrinopoulou EleniRosalina,
Tiddens Harm A. W. M.
Publication year - 2020
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24498
Subject(s) - bronchiectasis , medicine , cystic fibrosis , airway , asthma , high resolution computed tomography , respiratory disease , quality of life (healthcare) , disease , pediatrics , lung , surgery , nursing
Airway wall thickening and mucus plugging are important characteristics of cystic fibrosis (CF) lung disease in the first 5 years of life.The aim of this study is to investigate the association of lung disease in preschool children (age, 2‐6) with bronchiectasis and other clinical outcome measures in the school age (age >7). Deidentified computed tomography‐scans were annotated using Perth‐Rotterdam annotated grid morphometric analysis for CF. Preschool %disease (a composite score of %airway wall thickening, %mucus plugging, and %bronchiectasis) and %MUPAT (a composite score of %airway wall thickening and %mucus plugging) were used as predictors for %bronchiectasis and several other school‐age clinical outcomes. For statistical analysis, we used regression analysis, linear mixed‐effects models and two‐way mixed models. Sixty‐one patients were included. %Disease increased significantly with age ( P < .01). Preschool %disease and %MUPAT were significantly associated with school‐age %bronchiectasis ( P < .01 and P < .01, respectively). No significant association was found between preschool %disease and %MUPAT and school‐age forced expiratory volume 1 (FEV1%) predicted and quality of life ( P > .05). Cross‐sectional, %disease in school‐age was associated with a low FEV1% predicted and low quality of life ( P = .01 and P = .007, respectively). %Disease can be considered an early marker of diffuse airways disease and is a risk factor for school‐age bronchiectasis.