Premium
Profiles and characteristics of bronchial responsiveness in general 7‐year‐old children
Author(s) -
Park Ji Soo,
Choi Yun Jung,
Suh Dong In,
Jung Sungsu,
Kim YoungHo,
Lee SoYeon,
Yang SongI,
Kwon JiWon,
Jang Gwang Cheon,
Sun Yong Han,
Woo SungIl,
Youn YouSook,
Park Kang Seo,
Cho Hwa Jin,
Kook MyungHee,
Yi Hye Ryoung,
Chung Hai Lee,
Kim Ja Hyung,
Kim Hyung Young,
Jung Jin A,
Woo HyangOk,
Hong SooJong
Publication year - 2019
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24310
Subject(s) - medicine , methacholine , asthma , spirometry , provocation test , population , cohort , pediatrics , anesthesia , respiratory disease , lung , alternative medicine , environmental health , pathology
Background Although bronchial responsiveness (BR) is usually categorized as normal or hyperresponsive to aid the diagnosis of asthma, it exists on a continuous spectrum, not in a dichotomous manner. We aimed to evaluate the distribution profile of BR in a general population of 7‐year‐olds. Methods In 2015, 7‐year‐old Korean children from a nationwide birth cohort study visited regional study hospitals for skin prick test, standard spirometry, and bronchial provocation to establish reference values for the general population. Their BR degrees were categorized into five ordered groups: hyperresponsive BRs were classified into group 1 (provocative concentration (PC) of methacholine causing a 20% fall in forced expiratory volume in 1 second [FEV1], PC20 of <4 mg/mL) and group 2 (PC20 of ≥4 mg/mL and <16 mg/mL), and nonresponsive BRs were categorized into group 3 (final FEV1 percentage fall after inhaling 16 mg/mL of methacholine [FEV1%fall] of >15% and ≤20%), group 4 (FEV1%fall of >10% and ≤15%), and group 5 (FEV1%fall of ≤10%). Results In total, 559 subjects finished all tests reliably. Groups 1 and 2 comprised 10.0% and 15.7% of the total population, respectively. Groups 3, 4, and 5 comprised 14.7%, 18.4%, and 41.1%, respectively. As the group number increased, the proportion of those with recent wheezing and those with indoor allergen sensitization decreased ( P for trend = 0.001 and P for trend < 0.001, respectively), and the baseline FEV1/FVC increased ( P for trend < 0.001) Conclusion BR of the 7‐year‐olds in the general population, while showing a wide distribution across phenotypes, is associated with allergic symptoms, negatively correlated with baseline lung function and positively correlated with indoor allergen sensitization.