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Club cell secretory protein (CC16) in gastric fluid at birth and subsequent lung disease in preterm infants
Author(s) -
Hagman Cecilia,
Björklund Lars J.,
Hellgren Gunnel,
Tufvesson Ellen,
HansenPupp Ingrid
Publication year - 2018
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.24128
Subject(s) - medicine , gestational age , mechanical ventilation , gastroenterology , lung , gastric fluid , pregnancy , biology , chemistry , genetics , chromatography
Background Club cell secretory protein (CC16) probably has a role in protecting the lung from inflammation. Aim To evaluate if low levels of CC16 in gastric fluid at birth, reflecting low levels of CC16 in the lung, would be associated with lung inflammation and respiratory morbidity. Methods A study of 64 infants with mean gestational age 26.1 weeks. CC16 was analyzed in gastric fluid at birth. CC16, pro‐inflammatory cytokines, and MMP‐9 were analyzed in tracheal aspirate within 24 h from birth. Results CC16 in gastric fluid increased with gestational age ( P = 0.033). Lower concentrations of CC16 in gastric fluid at birth were associated with higher concentrations of IL‐1β ( P = 0.028), TNF‐α ( P = 0.034), and MMP‐9 ( P = 0.015) in tracheal aspirate. Infants who needed mechanical ventilation at 24 and 72 h of age had lower CC16 in gastric fluid than those not ventilated at these ages ( P = 0.011 and P = 0.024, respectively). Lower CC16 in gastric fluid was associated with higher FiO 2 at 6 h ( P = 0.009), higher PaCO 2 at 24 h ( P = 0.03), more ventilator days ( P = 0.012) and more days with supplemental oxygen ( P = 0.03). Infants who had either died or were still treated with supplemental oxygen at 36 weeks postmenstrual age had lower CC16 in gastric fluid than infants with none of these outcomes ( P = 0.049). Conclusion A low CC16 concentration in gastric fluid at birth was associated with increased inflammation in the trachea within the first 24 h of life and with more need for respiratory support in the neonatal period.