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Interleukin‐13 associates with life‐threatening rhinovirus infections in infants and young children
Author(s) -
Caballero Mauricio T.,
Hijano Diego R.,
Acosta Patricio L.,
Mateu Cecilia G.,
Marcone Débora N.,
Linder Jodell E.,
Talarico Laura B.,
Elder John M.,
Echavarria Marcela,
Miller Eva Kathryn,
Polack Fernando P.
Publication year - 2018
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23998
Subject(s) - medicine , rhinovirus , bronchiolitis , population , hypoxemia , pediatrics , prospective cohort study , respiratory system , immunology , environmental health
Objective Delineate risk factors associated with severe hypoxemia (O 2 sat ≤87%) in infants and children younger than 2 years hospitalized with single pathogen HRV infection. Study Design Prospective study in a yearly catchment population of 56 560 children <2 years old between 2011 and 2013 in Argentina. All children with respiratory signs and O 2 sat <93% on admission were included. HRV infections were identified by reverse transcriptase‐polymerase chain reaction. Epidemiologic, clinical, viral, and immunological risk factors were assessed. Results Among 5012 hospitalized patients, HRV was detected as a single pathogen in 347 (6.92%) subjects. Thirty‐two (9.2%) had life‐threatening disease. Traditional risk factors for severe bronchiolitis did not affect severity of illness. HRV viral load, HRV groups, and type II and III interferons did not associate with severe hypoxemia. Interleukin‐13 Levels in respiratory secretions at the time of admission (OR = 7.43 (3‐18.4); P < 0.001 for IL‐13 >10 pg/mL) predisposed to life‐threatening disease. Conclusions Targeted interventions against IL‐13 should be evaluated to decrease severity of HRV illness in infancy and early childhood.