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Longitudinal assessment of lung function in extremely prematurely born children
Author(s) -
Lo Jessica,
Zivanovic Sanja,
Lunt Alan,
AlcazarParis Mireia,
Andradi Gwendolyn,
Thomas Mark,
Marlow Neil,
Calvert Sandy,
Peacock Janet,
Greenough Anne
Publication year - 2018
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23933
Subject(s) - medicine , functional residual capacity , plethysmograph , lung volumes , bronchopulmonary dysplasia , gestational age , pulmonary function testing , airway , airway resistance , airway obstruction , pediatrics , cardiology , anesthesia , lung , pregnancy , biology , genetics
Objectives To assess longitudinally small airway function in children born extremely prematurely and whether there was a correlation between airway function in infancy and at 11‐14 years. Working Hypotheses There would be tracking of airways obstruction and s mall airway function would deteriorate during childhood in those born extremely prematurely. Study Design A longitudinal study. Patient‐Subject Selection Thirty‐five children with a mean gestational age of 26 weeks had lung function assessed at 1 year corrected and 11‐14 years of age. Methodology Lung volumes were measured by helium gas dilution (FRC He ) and plethysmography (FRC pleth ) and small airway function assessed by calculating the FRC He :FRC pleth ratio. Airway function was assessed at 1 year corrected by measurement of airway resistance (R aw ) and at 11‐14 years by assessment of R aw , forced expiratory flow from 75% of vital capacity (FEF 75 ), and forced expiratory volume at one second (FEV 1 ). Results At the first assessment, the children had a mean (SD) FRC He :FRC pleth of 0.90 (0.13) and at the second, 0.83 (0.12) ( P = 0.035). There was a significant 0.54% decrease (95%CI: −1.02%, −0.06%) in FRC He :FRC pleth for increased age per year after adjusting for birth weight, gestational age, sex, and bronchopulmonary dysplasia ( P = 0.027). There were significant correlations between R aw at the first assessment and R aw ( P = 0.012), FEF 75 ( P = 0.034), and FEV 1 ( P = 0.04) at 11‐14 years. Conclusions These results demonstrate in those born extremely prematurely there is tracking of airway function during childhood.