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Respiratory function and symptoms in young preterm children in the contemporary era
Author(s) -
Verheggen Maureen,
Wilson Andrew C.,
Pillow J. Jane,
Stick Stephen M.,
Hall Graham L.
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23487
Subject(s) - bronchopulmonary dysplasia , medicine , spirometry , respiratory system , pediatrics , lung function , gestation , gestational age , lung , asthma , pregnancy , genetics , biology
Summary Objective To determine the relationships between respiratory symptoms, lung function, and neonatal events in young preterm children. Methods Preterm children (<32 w gestation), classified as bronchopulmonary dysplasia (BPD) or non‐BPD, and healthy term controls were studied. Lung function was measured by forced oscillation technique (respiratory resistance [Rrs] and reactance [Xrs]) and spirometry. Respiratory symptom questionnaires were administered. Results One hundred and fifty children (74 BPD, 44 non‐BPD, 32 controls) 4–8 years were studied. Lung function (median Z‐score [10,90th centile]) was significantly impaired in preterm children compared to controls for FVC (0.00 [−1.18, 1.76], 0.69 [−0.17,1.86]), FEV 1 (−0.44 [−1.94, 1.11], 0.49 [−0.83, 2.51]), Xrs (−1.26 [−3.31, 0.11], −0.11 [−0.97, 0.73]), and Rrs (0.55 [−0.48, 1.82], 0.28 [−0.99, 0.96]). Only Xrs differed between the BPD and non‐BPD (−1.51 [−3.59, −0.41], −0.89 [−2.64, 0.52]). The prevalence of recent respiratory symptoms (range: 32–36%) did not differ between BPD and non‐BPD children. Supplemental O 2 in hospital was positively associated with worsening Xrs and FEV 1 . Conclusion Preterm children have worse lung function than healthy controls. Only respiratory reactance differentiated between preterm children with and without BPD and was influenced by days of O 2 in hospital. Pediatr Pulmonol. 2016;51:1347–1355. © 2016 Wiley Periodicals, Inc.