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Lung CT imaging in patients with bronchopulmonary dysplasia: A systematic review
Author(s) -
van Mastrigt Esther,
Logie Karla,
Ciet Pierluigi,
Reiss Irwin K.M.,
Duijts Liesbeth,
Pijnenburg Mariëlle W.,
Tiddens Harm A.W.M.
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23446
Subject(s) - medicine , bronchopulmonary dysplasia , radiology , lung , respiratory system , dysplasia , complication , computed tomography , respiratory disease , surgery , gestational age , pregnancy , genetics , biology
Summary Background Bronchopulmonary dysplasia (BPD) is a common respiratory complication of preterm birth and associated with long‐term respiratory sequelae. Chest computed tomography (CT) is a sensitive tool to obtain insight in structural lung abnormalities and may be a predictor for later symptoms. Objectives To give an overview of chest CT scoring methods that are used to evaluate chest CT scans of BPD patients. To review which structural lung abnormalities are described in children and adults with BPD and whether these are related to clinical outcomes. Methods An extensive literature search was conducted for relevant studies on chest CT imaging in patients born preterm with BPD. Results We retrieved 316 original papers of which 16 articles and three abstracts fulfilled our inclusion criteria. Overall, we identified nine different semi‐quantitative scoring methods. Chest CT scans revealed structural abnormalities in >85% of BPD patients. These abnormalities are decreased pulmonary attenuation, opacities, bronchial wall thickening, and consolidations. Some have been found to be negatively correlated with lung function and respiratory symptoms. Conclusions None of the currently described scoring systems are appropriately validated or superior over another. Future studies are needed to generate a validated and universal chest CT quantitative scoring method for patients with BPD. Pediatr Pulmonol. 2016; 51:975–986 . © 2016 Wiley Periodicals, Inc.