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Global and regional lung function in cystic fibrosis measured by electrical impedance tomography
Author(s) -
Lehmann Sylvia,
Leonhardt Steffen,
Ngo Chuong,
Bergmann Lukas,
Ayed Ines,
Schrading Simone,
Tenbrock Klaus
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23444
Subject(s) - electrical impedance tomography , medicine , spirometry , cystic fibrosis , lung , lung function , ventilation (architecture) , pulmonary function testing , lung ventilation , lung volumes , radiology , tomography , nuclear medicine , cardiology , asthma , mechanical engineering , engineering
Summary Background Electrical impedance tomography (EIT) delivers information about global and regional ventilation. Linearity of EIT during tidal breathing is known. We investigated the feasibility of EIT during lung function tests in pediatric patients with cystic fibrosis (CF) and healthy controls. Methods Eleven CF patients and 11 age‐matched controls underwent spirometry and simultaneous EIT. Global EIT results were scaled to spirometric forced vital capacity (FVC). Subsequently, global and regional “EIT‐spirometry” was calculated and correlated with clinical findings, radiology, and lung function results before and after bronchospasmolysis (BSL). Results Spirometry and global EIT results correlated essentially (r 2 = 0.71–1.0, P < 0.001). While lung function results were comparable for both groups, EIT demonstrated inhomogeneous ventilation and individual changes after BSL. Conclusions EIT changes during forced expiration correlate with lung function parameters, clinical findings, and radiology. Regional analysis of EIT illustrates regional lung function and visualizes individual therapeutic effects. Pediatr Pulmonol. 2016;51:1191–1199. © 2016 Wiley Periodicals, Inc.