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Lung function gain in preterm infants with and without bronchopulmonary dysplasia
Author(s) -
SanchezSolis Manuel,
PerezFernandez Virginia,
BoschGimenez Vicente,
Quesada Juan J.,
GarciaMarcos Luis
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23393
Subject(s) - bronchopulmonary dysplasia , medicine , lung function , lung , gain of function , pediatrics , lung disease , intensive care medicine , gestational age , pregnancy , genetics , biology , biochemistry , chemistry , gene , mutation
Summary Objectives The aim of our study was to determine whether the development of lung function, during the first 2 years of life, is different in preterm infants who suffered or did not suffer from Bronchopulmonary dysplasia (BPD). We also assessed the role of nutritional status and growth in that development. Methods Lung function tests were performed in 71 preterm infants at two time points: 6 months of corrected age and 1 year after. FVC, FEV0.5, FEF 75 , and FEF 25–75 were obtained from maximal expiratory volume curves by means of the raised volume rapid thoraco‐abdominal compression technique. Results When comparing lung function measurements, we found that FVC ( P = 0.033) FEV 0.5 ( P = 0.044), FEF 75 ( P = 0.014), and FEF 25–75 ( P = 0.036) were significantly lower in BPD infants. We did not find any catch‐up of lung function during the study time, in neither the whole group of children nor within the BPD or non‐BPD groups. The increase in lung function was directly proportional to the increase in weight and length. The multivariate analysis showed that the increase in z‐score of FVC ( P = 0.043), FEV 0.5 ( P = 0.015), and FEF 75 ( P = 0.042), was related with the height velocity during the study period. Conclusions Infants who suffered from BPD have lower lung function (FVC, FEV 0.5 , FEF 75 , and FEF 25–75 ), than those non‐BPD, at two different time points 1 year apart. During the study period, there was no lung function catch‐up in either BPD or non‐BPD infants. The increase in length is closely associated to the increase in lung function. Pediatr Pulmonol. 2016; 51:936–942 . © 2016 Wiley Periodicals, Inc.