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The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study
Author(s) -
Krogulska Aneta,
Dynowski Jarosław,
Jędrzejczyk Magdalena,
Sardecka Izabela,
Małachowska Beata,
WąsowskaKrólikowska Krystyna
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23373
Subject(s) - medicine , asthma , spirometry , provocation test , methacholine , allergen , food allergy , placebo , allergy , inhalation , concomitant , immunology , respiratory disease , anesthesia , lung , pathology , alternative medicine
Summary Background and Objective Despite the growing evidence of a possible link between asthma and food allergy (FA), so far, the involvement of food in inducing respiratory symptoms has not been fully evaluated. The objective of this study was to evaluate the impact of food allergens on respiratory symptoms and bronchial reactivity (BHR) in schoolchildren with asthma. Methods The initial study group consisted of 362 children with asthma. In the end, 22 children with concomitant FA, and 18 without FA, were selected to participate in the study. Spirometry and Methacholine Inhalation Challenge (MIC) were conducted prior to and after the completion of a double blind placebo control food challenge (DBPCFC). Results The food‐induced asthmatic reactions were observed in nine (2.5%) out of all 362 children with asthma. Mean FEV 1 prior to and after allergen or placebo challenge did not differ between the groups studied. Increase of BHR after DBPCFC was seen in 17 (4.7%) children with asthma. The mean PC 20 value in children with FA was 1.41 ± 1.12 mg/ml prior to the allergen challenge and 0.86 ± 0.71 mg/ml ( P = 0.002) after the test, whereas these values were 1.93 ± 1.68 mg/ml and 2.02 ± 1.75 mg/ml, respectively, in children without FA ( P > 0.05). Significant differences were noted after the allergen provocation in children with FA as compared to children without FA ( P = 0.007). Conclusions Although food allergens are a rare trigger of food‐induced asthmatic reactions in schoolchildren with asthma, they could enhance BHR, despite a lack of evident clinical respiratory signs and decreased in FEV 1 values after food challenge. Pediatr Pulmonol. 2016;51:787–795 . © 2016 Wiley Periodicals, Inc.