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Exacerbations in neuroendocrine cell hyperplasia of infancy are characterized by increased air trapping
Author(s) -
Houin Paul R.,
Deterding Robin R.,
Young Lisa R.
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23347
Subject(s) - medicine , tachypnea , air trapping , exacerbation , hypoxemia , failure to thrive , pediatrics , pulmonary function testing , radiology , tachycardia
Summary Neuroendocrine cell Hyperplasia of Infancy (NEHI) presents with tachypnea, retractions, hypoxemia, and often failure to thrive. The radiologic and physiologic findings in infants with NEHI have been well described with a distinct geographic pattern of ground‐glass opacities on chest computerized tomography imaging and profound air‐trapping on infant pulmonary function testing. Despite gradual improvement over time, unexplained exacerbation has been observed but not well characterized. We present physiological and radiological changes of increased air‐trapping during acute exacerbations in two older children with NEHI who had previously experienced significant clinical improvement. These cases illustrate previously undescribed manifestations of NEHI in older children. Pediatr Pulmonol. 2016;51:E9–E12 . © 2015 Wiley Periodicals, Inc.