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Peripheral quantitative computed tomography (pQCT) bone measurements in children with cystic fibrosis
Author(s) -
Bai Wei,
Binkley Teresa L.,
Wallace James W.,
Carver Terrence W.,
Specker Bonny L.
Publication year - 2016
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23323
Subject(s) - medicine , quantitative computed tomography , cystic fibrosis , lean body mass , bone mineral , cortical bone , bone density , osteoporosis , bone mineral content , endocrinology , anatomy , body weight
Summary Background Individuals with cystic fibrosis (CF) have low bone density and increased fracture risk. Methods Cross‐sectional study investigating whole body bone mineral content (WBBMC), bone geometry and strength in 12 children with CF compared to 23 age‐ and sex‐matched controls with and without adjusting for age, height, and body composition. Results CF group had lower WBBMC than controls ( P = 0.007) with larger differences at older ages (age‐by‐group, P = 0.08). CF group had decreased height ( P = 0.006), a trend of lower lean mass per height ( P = 0.08), and no difference in relationship between WBBMC and lean mass compared to controls ( P = 0.65). Periosteal and endosteal circumferences were smaller in CF (each, P = 0.02). Positive relationships of cortical area and bone strength with age were attenuated with CF (group‐by‐age; each, P < 0.01). Conclusion Children with CF have similar WBBMC relative to lean mass as controls. Cortical bone area and bone strength were less in CF group compared to controls, with greater differences in older children. Pediatr Pulmonol. 2016;51:28–33. © 2015 Wiley Periodicals, Inc.