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Does the FEF 25–75 or the FEF 75 have any value in assessing lung disease in children with cystic fibrosis or asthma?
Author(s) -
Lukic Karl Z.,
Coates Allan L.
Publication year - 2015
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23234
Subject(s) - medicine , cystic fibrosis , asthma , pediatrics , respiratory disease , disease , lung disease , lung , cardiology
Summary While the FEV 1 had been recognized as an excellent indicator of disability, it is not very sensitive to early and mild disease. In cystic fibrosis (CF) small airway disease is believed to be one of the early hallmarks and indices such as the FEF 25–75 and FEF 75 have been proposed as sensitive markers of early disease. The site of early disease in asthma is not as well worked out. Recently a study of more than 20,000 spirometries found that neither of these indices added anything to the FEV 1 /FVC but that study was not disease specific and contained both adults and children and the adults were the most numerous. To see if this would be true in children, 1,175 spirograms from children 6 to 18 years of age with CF or asthma whose FEV 1 and FVC were above the lower limit of normal were taken from sequential studies. The data expressed in z scores was plotted with either the FEF 25–75 or FEF 75 plotted against FEV 1 /FVC. In both diseases, but particularly in asthma, the FEV 1 /FVC was more likely to be abnormal than either of the other two indices for suggesting that for children, early, or mild disease will be more apparent using the FEV 1 /FVC than any other index. Pediatr Pulmonol. 2015; 50:863–868. © 2015 Wiley Periodicals, Inc.