Premium
Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans
Author(s) -
Tanou Kalliopi,
Xaidara Athina,
Kaditis Athanasios G.
Publication year - 2015
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23157
Subject(s) - medicine , bronchiolitis obliterans , spirometry , plethysmograph , pulse oximetry , air trapping , pulmonary function testing , immunosuppression , anesthesia , asthma , lung , lung transplantation
Summary Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air‐trapping and improvement in expiratory function and nocturnal oxygenation during and after six three‐day courses of high‐dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans. Pediatr Pulmonol. 2015; 50:E13–E16. © 2015 Wiley Periodicals, Inc.