Premium
Lung parenchymal development in premature infants without bronchopulmonary dysplasia
Author(s) -
Assaf Santiago J.,
Chang Daniel V.,
Tiller Christina J.,
Kisling Jeffrey A.,
Case Jamie,
Mund Julie A.,
Slaven James E.,
Yu Zhangsheng,
Ahlfeld Shawn K.,
Poindexter Brenda,
Haneline Laura S.,
Ingram David A.,
Tepper Robert S.
Publication year - 2015
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23134
Subject(s) - bronchopulmonary dysplasia , medicine , dlco , gestational age , lung , lung volumes , continuous positive airway pressure , cardiology , diffusing capacity , lung function , pregnancy , genetics , obstructive sleep apnea , biology
Summary Rationale: While infants who are born extremely premature and develop bronchopulmonary dysplasia (BPD) have impaired alveolar development and decreased pulmonary diffusion (DL CO ), it remains unclear whether infants born less premature and do not develop BPD, healthy premature (HP), have impaired parenchymal development. In addition, there is increasing evidence that pro‐angiogenic cells are important for vascular development; however, there is little information on the relationship of pro‐angiogenic cells to lung growth and development in infants. Objective and Methods Determine among healthy premature (HP) and fullterm (FT) infants, whether DL CO and alveolar volume (V A ) are related to gestational age at birth (GA), respiratory support during the neonatal period (mechanical ventilation [MV], supplemental oxygen [O 2 ], continuous positive airway pressure [CPAP]), and pro‐angiogenic circulating hematopoietic stem/progenitor cells (CHSPCs). We measured DL CO , V A , and CHSPCs in infants between 3–33 months corrected‐ages; HP (mean GA = 31.7 wks; N = 48,) and FT (mean GA = 39.3 wks; N = 88). Result DL CO was significantly higher in HP than FT subjects, while there was no difference in V A , after adjusting for body length, gender, and race. DL CO and V A were not associated with GA, MV and O 2 ; however, higher values were associated with higher CHSPCs, as well as treatment with CPAP. Conclusion Our findings suggest that in the absence of extreme premature birth, as well as BPD, prematurity per se, does not impair lung parenchymal development. Pediatr Pulmonol. 2015; 50:1313–1319. © 2014 Wiley Periodicals, Inc.