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Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus
Author(s) -
Maduekwe Echezona T.,
Buczynski Bradley W.,
Yee Min,
Rangasamy Tiruamalai,
Stevens Timothy P.,
Lawrence B. Paige,
O'Reilly Michael A.
Publication year - 2015
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23063
Subject(s) - medicine , respiratory system , oxygen , lung , immunology , influenza a virus , physiology , anesthesia , virus , chemistry , organic chemistry
Summary An acceptable level of oxygen exposure in preterm infants that maximizes efficacy and minimizes harm has yet to be determined. Quantifying oxygen exposure as an area‐under‐the curve (O AUC ) has been predictive of later respiratory symptoms among former low birth weight infants. Here, we test the hypothesis that quantifying O AUC in newborn mice can predict their risk for altered lung development and respiratory viral infections as adults. Newborn mice were exposed to room air or a FiO 2 of 100% oxygen for 4 days, 60% oxygen for 8 days, or 40% oxygen for 16 days (same cumulative dose of excess oxygen). At 8 weeks of age, mice were infected intranasally with a non‐lethal dose of influenza A virus. Adult mice exposed to 100% oxygen for 4 days or 60% oxygen for 8 days exhibited alveolar simplification and altered elastin deposition compared to siblings birthed into room air, as well as increased inflammation and fibrotic lung disease following viral infection. These changes were not observed in mice exposed to 40% oxygen for 16 days. Our findings in mice support the concept that quantifying O AUC over a currently unspecified threshold can predict human risk for respiratory morbidity later in life. Pediatr Pulmonol. 2015; 50:222–230. © 2014 Wiley Periodicals, Inc.