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Validation of multiple‐breath washout equipment for infants and young children
Author(s) -
Schmidt Anne,
Yammine Sophie,
Proietti Elena,
Frey Urs,
Latzin Philipp,
Riedel Thomas,
Singer Florian
Publication year - 2015
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.23010
Subject(s) - medicine , washout , nitrogen washout , pediatrics , intensive care medicine , functional residual capacity , lung volumes , lung
Summary Introduction The new ATS/ERS consensus report recommends in vitro validation of multiple‐breath inert gas washout (MBW) equipment based on a lung model with simulated physiologic conditions. We aimed to assess accuracy of two MBW setups for infants and young children using this model, and to compare functional residual capacity (FRC) from helium MBW (FRC MBW ) with FRC from plethysmography (FRC pleth ) in vivo. Methods The MBW setups were based on ultrasonic flow meter technology. Sulfur hexafluoride and helium were used as tracer gases. We measured FRC in vitro for specific model settings with and without carbon dioxide and calculated differences of measured to generated FRC. For in vivo evaluation, difference between FRC MBW and FRC pleth was calculated in 20 healthy children, median age 6.1 years. Coefficient of variation (CV) was calculated per FRC. Results In the infant model (51 runs, FRC 80–300 ml), mean (SD) relative difference between generated and measured FRCs was 0.7 (4.7) %, median CV was 4.4% for measured FRCs. In the young child model, one setting (8 runs, FRC 400 ml) showed a relative difference of up to 13%. For the remaining FRCs (42 runs, FRC 600–1,400 ml), mean (SD) relative difference was −2.0 (3.4) %; median CV was 1.4% for measured FRCs. In vivo FRC pleth exceeded FRC MBW values by 37% on average. Conclusions Both setups measure lung volumes in the intended age group reliably and reproducibly. Characteristics of different techniques should be considered when measuring lung volumes in vivo. Pediatr Pulmonol. 2015; 50:607–614. © 2014 Wiley Periodicals, Inc.