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Physiological correlates of pulmonary function in children with cystic fibrosis
Author(s) -
Wells Greg D.,
Wilkes Donna L.,
Schneiderman Jane E.,
Thompson Sara,
Coates Allan L.,
Ratjen Felix
Publication year - 2014
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22928
Subject(s) - anaerobic exercise , medicine , cystic fibrosis , grip strength , pulmonary function testing , vo2 max , vertical jump , physical therapy , cardiology , aerobic exercise , jump , heart rate , blood pressure , physics , quantum mechanics
Summary Rationale Although peak aerobic capacity (VO 2peak ) has been linked to outcome in patients with cystic fibrosis (CF), measuring is time consuming, and requires expensive equipment and expertise that is not readily available in all centers. Other fitness parameters such as peak anaerobic power, measures of power and strength may be simpler to deliver in the clinic. The relationship between these measures and established outcomes such as forced expiratory volume in one second (FEV 1 ) and peak aerobic power (VO 2peak ) in CF remains unclear. Therefore we evaluated (a) aerobic fitness, (b) anaerobic fitness, and (c) upper and lower body muscle strength to determine their relationship to FEV 1 and VO 2peak in children with CF. Methods Eighty‐two patients (7–18 years) with CF (40 female) from the CF clinic at The Hospital for Sick Children in Toronto performed a maximal incremental cycling test to exhaustion. Anaerobic power (W) for 10 and 30 sec cycling trials as well as vertical jump (VJ) and hand grip strength (HG) were compared to FEV 1 and VO 2peak . Results Absolute VO 2peak (R 2 = 0.16, P < 0.001), anaerobic power (R 2 = 0.21, P < 0.001), and hand grip strength (R 2 = 0.10, P = 0.003) were significantly correlated to lung function whereas measures of explosive lower body strength (VJ) were not. Anaerobic power (R 2 = 0.16, P = 0.001) and hand grip strength (R 2 = 0.08, P = 0.01) were related to VO 2peak . Vertical jump was correlated with VO 2peak (R 2 = 0.29, P < 0.001) but not FEV 1 . Conclusions Simple fitness tests such as hand grip strength and anaerobic cycle tests may be useful indicators of lung health and fitness. Pediatr Pulmonol. 2014; 49:878–884. © 2013 Wiley Periodicals, Inc.