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Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: A systematic review and meta‐analysis
Author(s) -
McNally J. Dayre,
Sampson Margaret,
Matheson Loren A.,
Hutton Brian,
Little Julian
Publication year - 2014
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22877
Subject(s) - foki , calcitriol receptor , bronchiolitis , medicine , taqi , meta analysis , genotype , odds ratio , vitamin d and neurology , allele , gastroenterology , immunology , polymorphism (computer science) , genetics , biology , respiratory system , gene
Abstract Background A number of small studies have suggested a relationship between vitamin D status and severe acute lower respiratory tract infection (ALRI), including RSV—bronchiolitis. The objective of this study was to evaluate the relationship between vitamin D receptor ( VDR ) polymorphism and severe RSV‐bronchiolitis through a systemic literature review and meta‐analysis. Methods A comprehensive electronic literature search was conducted to identify all studies published before January 2013. Two reviewers independently screened all abstracts, followed by the full text of potential articles to evaluate eligibility. Study methodological quality was evaluated using the Newcastle Ottawa scale and individual component analysis. Meta‐analysis evaluated associations at the allele and genotype levels. Results Of 803 studies identified from our literature search, three met eligibility criteria. Two VDR polymorphisms were included in more than one study: Taq I (rs731236) and Fok I (rs2228570). All three reported a positive relationship between the Fok I minor allele and disease with random effects meta‐analyses demonstrating a statistically significant relationship (OR 1.52, CI: 1.12, 2.05). Genotype analysis was highly suggestive of a dominant or incomplete dominance model with combined odds ratios for fF (OR 1.73, CI: 0.92–3.36) and ff (OR 2.24, CI: 0.98–5.14) compared to the FF genotype. No association between Taq I and severe RSV‐bronchiolitis was evident at the allele or genotype level. Conclusions Available literature supports an association between the Fok I polymorphism and severe RSV disease. Determination of VDR receptor polymorphism status could help predict high‐risk infants who might benefit from preventive measures. Pediatr Pulmonol. 2014; 49:790–799. © 2013 Wiley Periodicals, Inc.