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Propranolol as a treatment option in Gorham–Stout syndrome: A case report
Author(s) -
Nir Vered,
Guralnik Ludmila,
Livnat Galit,
BarYoseph Ronen,
Hakim Fahed,
Ilivitzki Anat,
Bentur Lea
Publication year - 2014
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22869
Subject(s) - medicine , propranolol , mediastinum , pericardium , angiomatosis , surgery , rib cage , anatomy , dermatology
Summary Gorham–Stout syndrome is a very rare syndrome characterized by progressive angiomatosis and lymphangiomas involving multiple organs. We describe herein a girl with progressive Gorham–Stout syndrome since the age of 13 years. Her disease involved the mediastinum, pericardium, vertebrae, ribs, and skull and did not respond to interferon and bisphosphonates. Propranolol administration was initiated at the age of 18 years and was associated with improvement in pulmonary function tests and involution of the mediastinal and hilar hemangiomatous lesions. The possible beneficial effect of propranolol in Gorham–Stout syndrome should be further investigated. Pediatr Pulmonol. 2014; 49:417–419. © 2013 Wiley Periodicals, Inc.