Premium
Serum insulin‐like growth factor‐1 (IGF‐1) during CF pulmonary exacerbation: Trends and biomarker correlations
Author(s) -
Gifford A.H.,
Nymon A.B.,
Ashare A.
Publication year - 2014
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22822
Subject(s) - medicine , exacerbation , insulin like growth factor , endocrinology , body mass index , transferrin saturation , biomarker , anabolism , pulmonary function testing , growth factor , anemia , iron deficiency , receptor , biochemistry , chemistry
Summary Introduction Cystic fibrosis (CF) is characterized by low circulating levels of insulin‐like growth factor‐1 (IGF‐1), a hormone produced by the liver that governs anabolism and influences immune cell function. Because treatment of CF pulmonary exacerbation (CFPE) often improves body weight and lung function, we questioned whether serum IGF‐1 trends were emblematic of these responses. Initially, we compared serum levels between healthy adults with CF and controls of similar age. We then measured serum IGF‐1 throughout the CFPE cycle. We also investigated correlations among IGF‐1 and other serum biomarkers during CFPE. Methods Anthopometric, spirometric, and demographic data were collected. Serum IGF‐1 concentrations were measured by ELISA. Results CF subjects in their usual state of health had lower serum IGF‐1 levels than controls. Serum IGF‐1 concentrations fell significantly from baseline at the beginning of CFPE. Treatment with intravenous antibiotics was associated with significant improvement in serum IGF‐1 levels, body mass index (BMI), and percent‐predicted forced expiratory volume in 1 sec (FEV 1 %). At early and late CFPE, serum IGF‐1 was directly correlated with FEV 1 %, serum iron, hemoglobin concentration, and transferrin saturation (TSAT) and indirectly correlated with alpha‐1‐antitrypsin. Conclusions This study not only supports the paradigm that CF is characterized by IGF‐1 deficiency but also that trends in lung function, nutritional status, and serum IGF‐1 are related. Improvements in all three parameters after antibiotics for CFPE likely highlight the connection between lung function and nutritional status in CF. Close correlations among IGF‐1 and iron‐related hematologic parameters suggest that IGF‐1 may participate in CF iron homeostasis, another process that is known to be influenced by CFPE. Pediatr Pulmonol. 2014; 49:335–341. © 2013 Wiley Periodicals, Inc.