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Refractory otitis media: An unusual presentation of childhood granulomatosis with polyangiitis
Author(s) -
Uppal Preena,
Taitz Jonny,
Wainstein Brynn,
Soma Marlene,
Belessis Yvonne,
Gray Paul
Publication year - 2014
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22746
Subject(s) - medicine , otitis , granulomatosis with polyangiitis , pneumonia , dermatology , vasculitis , refractory (planetary science) , pleural effusion , sensorineural hearing loss , pediatrics , pathology , hearing loss , surgery , disease , audiology , physics , astrobiology
Childhood granulomatosis with polyangiitis (cGPA), previously known as Wegener's granulomatosis, is a rare, potentially fatal necrotizing vasculitis, the symptoms of which overlap with infection. We present a 16‐year‐old girl who, following 6 months of treatment for persistent middle ear effusion with progressive sensorineural hearing loss, developed rapidly progressing pneumonia, with pleural effusion, and multiple cavitatory lung lesions. Investigations demonstrated high titer c‐ANCA and nasal septal biopsy confirmed the diagnosis of cGPA. This case highlights the difficulty in diagnosing cGPA and the potentially life‐threatening consequences of failing to do so. Pediatr Pulmonol. 2014; 49:E21–E24. © 2013 Wiley Periodicals, Inc.