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Nanomedicine as an innovative therapeutic strategy for pediatric lung diseases
Author(s) -
Tian Ye,
Chen Jian,
Zahtabi Fatemeh,
Keijzer Richard,
Xing Malcolm
Publication year - 2013
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22657
Subject(s) - nanomedicine , medicine , nanotechnology , drug delivery , nanoparticle , materials science
Nanomedicine is a rapidly emerging technology and represents an innovative field for therapy. Nanomaterials have intrinsically defined features for biomedical applications due to the high specific surface area, the amazing diversity, versatility in structure and function and the possibility of surface charge. In particular, the functionalization of targeting or stimuli‐responsive unit on the surface of these materials gives them specific targeted therapeutic properties. There are many pediatric lung diseases that could potentially benefit from nanomedicine. Herein, we aim to review various drug carrier systems and release systems specifically targeting pediatric lung diseases. The injection of nanomedicine into in vivo models and their elimination will also be discussed. Finally, the potential toxicity of nanomaterials will be addressed. Pediatr Pulmonol. 2013; 48:1098–1111. © 2013 Wiley Periodicals, Inc.