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Severe central sleep apnea in a child with leukemia on chronic methadone therapy
Author(s) -
Amos Louella B.,
D'Andrea Lynn A.
Publication year - 2013
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22539
Subject(s) - medicine , methadone , central sleep apnea , pediatrics , anesthesia , myeloid leukemia , chemotherapy , sleep apnea , opioid , apnea , intensive care medicine , polysomnography , receptor
We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management. His chemotherapy‐related cerebral atrophy and renal insufficiency with impaired methadone clearance may have also contributed to the severity of his sleep‐disordered breathing. Maintenance methadone treatment is not a common pediatric practice; therefore, the adverse effects of methadone therapy, including CSA, are rarely reported in children. Pediatr Pulmonol. 2013; 48:85–87. © 2012 Wiley Periodicals, Inc.