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Malignant pleural mesothelioma in a child with ataxia–telangiectasia
Author(s) -
RosasSalazar Christian,
Gunawardena Sriya W.,
Spahr Jonathan E.
Publication year - 2013
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22535
Subject(s) - medicine , ataxia telangiectasia , pleural disease , telangiectasia , respiratory disease , lung cancer , population , disease , immunodeficiency , mesothelioma , dermatology , pathology , lung , pediatrics , immunology , dna , genetics , immune system , environmental health , dna damage , biology
Ataxia–telangiectasia (AT) is a hereditary disorder characterized by progressive neurological dysfunction, oculocutaneous telangiectasia, immunodeficiency, cancer susceptibility, and radiation sensitivity. Pleural neoplasms are extremely rare in the pediatric population, even in patients with AT. We describe the case of a 16‐year‐old male with AT who developed a malignant pleural mesothelioma (MPM). Benign or infectious lung and pleural diseases are common in those with AT. Hence, delayed diagnosis of respiratory neoplasms can occur in these patients. This report highlights the need of heightened vigilance in patients with AT with recurrent or persistent pleuropulmonary disease. To our knowledge, no other cases of MPM in children with AT have been reported. Pediatr Pulmonol. 2013; 48:94–97. © 2012 Wiley Periodicals, Inc.