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Lung aeration changes after lung recruitment in children with acute lung injury: A feasibility study
Author(s) -
Boriosi Juan P.,
Cohen Ronald A.,
Summers Evan,
Sapru Anil,
Hanson James H.,
Gildengorin Ginny,
Newman Vivienne,
Flori Heidi R.
Publication year - 2012
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.22508
Subject(s) - interquartile range , medicine , lung , fraction of inspired oxygen , hypercapnia , anesthesia , aeration , respiratory system , mechanical ventilation , chemistry , organic chemistry
Rationale There are several adult studies using computed tomography (CT‐scan) to examine lung aeration changes during or after a recruitment maneuver (RM) in ventilated patients with acute lung injury (ALI). However, there are no published data on the lung aeration changes during or after a RM in ventilated pediatric patients with ALI. Objective To describe CT‐scan lung aeration changes and gas exchange after lung recruitment in pediatric ALI and assess the safety of transporting patients in the acute phase of ALI to the CT‐scanner. Methods We present a case series completed in a subset of six patients enrolled in our previously published study of efficacy and safety of lung recruitment in pediatric patients with ALI. Intervention: RM using incremental positive end‐expiratory pressure. Results There was a variable increase in aerated and poorly aerated lung after the RM ranging from 3% to 72% (median 20%; interquartile range 6, 47; P = 0.03). All patients had improvement in the ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO 2 /FiO 2 ) after the RM (median 14%; interquartile range: 8, 72; P = 0.03). There was a decrease in the partial pressure of arterial carbon dioxide (PaCO 2 ) in four of six subjects after the RM (median −5%; interquartile range: −9, 2; P = 0.5). One subject had transient hypercapnia (41% increase in PaCO 2 ) during the RM and this correlated with the smallest increase (3%) in aerated and poorly aerated lung. All patients tolerated the RM without hemodynamic compromise, barotrauma, hypoxemia, or dysrhythmias. Conclusions Lung recruitment results in improved lung aeration as detected by lung tomography. This is accompanied by improvements in oxygenation and ventilation. However, the clinical significance of these findings is uncertain. Transporting patients in early ALI to the CT‐scanner seems safe and feasible. Pediatr Pulmonol. 2012. 47:771–779. © 2012 Wiley Periodicals, Inc.