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Comparative repeatability of two handheld fractional exhaled nitric oxide monitors
Author(s) -
Kapande Kirsty M.,
McConaghy Laura A.,
Douglas Isabella,
McKenna Sonia,
Hughes Jenny L.,
McCance David R.,
Ennis Madeline,
Shields Michael D.
Publication year - 2012
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21591
Subject(s) - exhaled nitric oxide , repeatability , medicine , significant difference , mean difference , exhalation , limits of agreement , asthma , exhaled air , population , anesthesia , nuclear medicine , statistics , mathematics , toxicology , confidence interval , spirometry , environmental health , biology
Background The use of portable fractional exhaled nitric oxide (FENO) devices is increasingly common in the diagnosis and management of allergic airways inflammation. Methods We tested two handheld FENO devices, to determine (a) if there was adequate intradevice repeatability to allow the use of single breath testing, and (b) if the devices could be used interchangeably. In a mixed pediatric population, including normal, asthmatic, and children with peanut allergies, 858 paired values were collected from the NIOX‐MINO® and/or the NObreath® devices. Results The NIOX‐MINO® showed excellent repeatability (mean difference of 0.1 with 95% limits of agreement between −7.93 to 7.72 ppb), while the NObreath® showed good repeatability (mean difference of −1.61 with 95% limits of agreement between −14.1 and 10.8 ppb). Intradevice repeatability was good but not adequate and the NIOX‐MINO® systematically produced higher results than the NObreath® [mean difference of 7.8 ppb with 95% limits of agreement from −11.55 to 27.52 ppb (−33% to 290%)]. Conclusions Our results support the manufacturer's advice that single breath testing is appropriate for the NIOX‐MINO®. NObreath® results indicate that the mean of more than one breath should be utilized. The devices cannot be used interchangeably. Pediatr Pulmonol. 2012; 47:546–550. © 2011 Wiley Periodicals, Inc.