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Hospitalized children with 2009 influenza a (H1N1) infection in Shenzhen, China, november–december 2009
Author(s) -
Zheng Yuejie,
He Yanxia,
Deng Jikui,
Lu Zhiwei,
Wei Jurong,
Yang Weiguo,
Tang Zhengzhen,
Li Boning,
Zhang Jaosheng,
Wang Li,
Zhao Hui,
Li Xiaonan,
Yu Zhenzhu,
Song Ping,
Ma Yijiao,
Li Yingfei,
Li Chengrong
Publication year - 2011
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21359
Subject(s) - medicine , china , pediatrics , covid-19 , emergency medicine , virology , outbreak , disease , infectious disease (medical specialty) , political science , law
Objectives During the winter outbreak of 2009 influenza A (H1N1) infection in China, the number of confirmed cases and the fatal cases has grown rapidly. We describe the clinical characteristics of hospitalized children with 2009 influenza A (H1N1) infection in Shenzhen, China, November–December 2009. Methods Using a standardized form, we collected data on 148 hospitalized children. 2009 influenza A (H1N1) infection was confirmed in nasopharyngeal swab specimens with the use of a real‐time reverse transcriptase‐polymerase chain reaction assay. Results Of the 148 hospitalized children with 2009 influenza A (H1N1) infection, 81 (55%) were 5 years of age or older and 85% of the patients were previously healthy. The common presenting symptoms were fever (94%), cough (89%), runny nose (36.5%), vomiting (24%), sore throat (19.6%), wheezing (18%), abdominal pain (16%), mental status changes (9%), seizures (6%), diarrhea (6%), myalgia (6%), and chest pain (4%). Twenty‐nine (20%) patients were admitted to an ICU, 10 (7%) patients required mechanical ventilation. The overall complication rate was 65.5%, they were pneumonia in 94 (64%), neurologic complications in 18 (12%), parapneumonic effusion in 12 (8%) and myocarditis in 7 (5%). One hundred seven (72%) patients received oseltamivir treatment, 34 (23%) received within 48 hr after the onset of symptoms. All patients received antibiotics before admission or on admission. One hundred forty‐four (97%) patients were discharged; four (3%) previously healthy patients died, three died from severe encephalopathy, one died from secondary fungal meningitis. Conclusion Hospitalized children with 2009 influenza A (H1N1) infection can have a wide range of presentation and clinical complications including neurologic complications. The severe cases and deaths concentrate in previously healthy older children. Pediatr Pulmonol. 2011; 46:246–252. © 2011 Wiley‐Liss, Inc.