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Iron and CF‐related anemia: Expanding clinical and biochemical relationships
Author(s) -
Gifford A.H.,
Miller S.D.,
Jackson B.P.,
Hampton T.H.,
O'Toole G.A.,
Stanton B.A.,
Parker H.W.
Publication year - 2011
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21335
Subject(s) - medicine , sputum , cystic fibrosis , anemia , gastroenterology , lung function , lung , tuberculosis , pathology
Abstract Introduction This cross‐sectional study was conducted to assess the relationship between iron levels in the plasma and sputum of cystic fibrosis (CF) patients. Methods Demographic, clinical, and iron‐related laboratory data were prospectively obtained from 25 patients with stable clinical features and 14 patients with worsened clinical features since their most recent evaluations. Results Compared to patients with stable clinical features, those who experienced clinical deterioration demonstrated significantly worse lung function and were more frequently malnourished and diabetic. Members of the latter group were also significantly more hypoferremic and had higher sputum iron content than patients with stable clinical features. No significant correlation was found between plasma and sputum iron levels when the groups were analyzed together and separately. Conclusions Sputum iron content does not correlate with iron‐related hematologic tests. Hypoferremia is common in CF and correlates with poor lung function and overall health. Pediatr. Pulmonol. 2011; 46:160–165. © 2011 Wiley‐Liss, Inc.