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“Atypical steroid response” in a pulmonary inflammatory myofibroblastic tumor
Author(s) -
Sacco Oliviero,
Gambini Claudio,
Gardella Chiara,
Tomà Paolo,
Rossi Umberto G.,
Jasonni Vincenzo,
Bush Andrew,
Rossi Giovanni A.
Publication year - 2010
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21237
Subject(s) - medicine , thoracotomy , prednisone , atelectasis , lesion , biopsy , mediastinal tumor , immunosuppression , mass/lesion , radiology , pathology , surgery , lung , mediastinum
A 6‐year‐old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well‐circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor. Pediatr Pulmonol. 2010; 45:721–726. © 2010 Wiley‐Liss, Inc.