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Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation
Author(s) -
Atwa Khalid,
Abuhasna Said,
Shihab Zuhair,
Hashaykeh Nidal,
Hasan Rashed
Publication year - 2010
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21139
Subject(s) - medicine , bleomycin , pulmonary toxicity , respiratory distress , pneumomediastinum , lung , surgery , pneumothorax , hypoxemia , anesthesia , chemotherapy
Objective To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. Design Case report. Setting A tertiary care University‐affiliated hospital. Patient, Intervention, and Results An 8‐month‐old girl developed acute respiratory distress with profound hypoxemia complicated by pneumothorax and pneumomediastinum 1 day following intralesional administration of bleomycin. She was treated with bilateral chest tube insertion, systemic corticosteroids, pentoxifylline, and supportive care. At the most recent follow‐up 5 months after the onset of the respiratory event, the patient is active, walks, and talks without any evidence of pulmonary diseases clinically. This is the youngest infant reported, to date, with acute bleomycin pulmonary toxicity following intralesional administration of bleomycin resulting in acute respiratory insufficiency followed by complete recovery. Conclusions This case illustrates the importance of early recognition and aggressive treatment of acute bleomycin toxicity resulting from intralesional administration of this medication for lymphovenous malformations. Pediatr Pulmonol. 2010; 45:192–196. © 2009 Wiley‐Liss, Inc.