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Post‐infectious bronchiolitis obliterans: Can CT scan findings at early age anticipate lung function?
Author(s) -
Mattiello Rita,
Sarria Edgar E.,
Mallol Javier,
Fischer Gilberto B.,
Mocelin Helena,
Bello Rodrigo,
Flores Jose A.M.,
Irion Klaus,
Jones Yvonne
Publication year - 2010
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21115
Subject(s) - medicine , bronchiolitis obliterans , lung function , bronchiolitis , computed tomography , lung , radiology , pulmonary function testing , stage (stratigraphy) , pediatrics , respiratory system , lung transplantation , paleontology , biology
Background The image findings of post‐infectious bronchiolitis obliterans (PIBO) have been described, however, we do not know if such findings can predict lung function (LF) deterioration with increasing patient age. Aim: To assess whether computed tomography (CT) abnormalities detected at an early stage of the disease can anticipate abnormal LF a decade later in children with PIBO. Methods We compared CT scans of 21 children with PIBO, done within their first 3 years of life, and their actual LF. To evaluate CT scans we used a modified Bhalla score and, for LF, FEV1 as percentage of predicted values. We calculated prevalence ratios (PRs) by comparing the proportion of patients with worst CT score and worst LF, with the proportion of those with best CT score and worst LF. Results PR was 1.17 (CI 1.02; 1.34, P = 0.02). Conclusions The CT finding early in the life of children with PIBO, when assessed by the Bhalla, score seem to anticipate future LF status. Pediatr Pulmonol. 2010; 45:315–319. © 2010 Wiley‐Liss, Inc.