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Pediatric obstructive sleep apnea: A potential late consequence of respiratory syncitial virus bronchiolitis
Author(s) -
Snow Ayelet,
Dayyat Ehab,
MontgomeryDowns Hawley E.,
KheirandishGozal Leila,
Gozal David
Publication year - 2009
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21109
Subject(s) - bronchiolitis , medicine , pediatrics , apnea of prematurity , asthma , apnea , obstructive sleep apnea , gestational age , population , respiratory system , body mass index , pregnancy , environmental health , biology , genetics
Study Objectives To examine the hypothesis that children who suffered from severe respiratory syncitial virus (RSV) bronchiolitis during infancy may be at higher risk for obstructive sleep apnea (OSA) later in childhood. Methods Survey of Kosair Children's Hospital medical records allowed for identification of potential candidates for the study. Twenty‐one randomly selected children (mean age ± SD: 5.2 ± 1.5 years) with a history of verified RSV‐induced bronchiolitis during their first year of life underwent overnight sleep study (NPSG). Children recruited from the general population with no history of RSV bronchiolitis served as a control group. After matching for age, gender, ethnicity, gestational age at birth, body mass index (BMI) z scores, household cigarette smoking, history of asthma and allergies, 63 control subjects (mean age ± SD: 5.1 ± 0.7 years) were also studied. Results Children who had RSV bronchiolitis as infants had significantly higher obstructive apnea/hypopnea index compared to controls (2.3 ± 1.9 vs. 0.6 ± 0.8 /hr total sleep time (TST); P < 0.05). In addition, significantly higher respiratory arousal indices were apparent among children with previous RSV bronchiolitis compared to controls (1.3 ± 1.0 vs. 0.1 ± 0.2 /hr TST; P < 0.05). There were no significant differences between the groups in the lowest SpO 2 , ETCO 2 , and sleep indices. Conclusions RSV bronchiolitis may contribute to the pathophysiology of OSA in vulnerable children. Pediatr Pulmonol. 2009; 44:1186–1191. © 2009 Wiley‐Liss, Inc.