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Renal dysfunction in cystic fibrosis: Is there cause for concern?
Author(s) -
Soulsby Natalie,
Greville Hugh,
Coulthard Kingsley,
Doecke Christopher
Publication year - 2009
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.21086
Subject(s) - medicine , cystic fibrosis , intensive care medicine , life expectancy , disease , lung disease , lung function , lung , cystatin c , kidney disease , renal function , population , environmental health
Most people associate cystic fibrosis (CF) with lung disease. Although this is the major cause of morbidity and mortality, CF is in fact a multi‐organ disease. Patients with CF are living longer. Accompanying their increased life expectancy are complications not previously encountered. One of the less obvious concerns is that of renal dysfunction associated with long‐term exposure to aminoglycosides as well as renally toxic immunosuppressants in lung transplant recipients. This article reviews what is known about the extent of the problem, summarizes what the current practices of measuring and monitoring renal function in patients with CF, and makes suggestions for alternative approaches. In particular, the potential role of cystatin C will be discussed. Pediatr Pulmonol. 2009; 44:947–953. ©2009 Wiley‐Liss, Inc.