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Management of the pediatric organ donor to optimize lung donation
Author(s) -
Mallory George B.,
Schecter Marc G.,
Elidemir Okan
Publication year - 2009
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20997
Subject(s) - medicine , organ donation , intensive care medicine , limiting , lung transplantation , lung , organ transplantation , lung disease , transplantation , disease , donation , organ system , pathology , surgery , mechanical engineering , engineering , economics , economic growth
Abstract Lung transplantation in childhood is a highly specialized clinical practice confined to a few centers around the world. Organ availability remains an important limiting factor in extending the application of this procedure to more infants, children and adolescents. The lungs are the organ most vulnerable to injury, infection and dysfunction among transplantable organs in the brain dead deceased donor. In this manuscript, we review the pathophysiology of the most common and important disease states that affect the lungs in potential donors. Furthermore, we herein provide recommendations for optimal management of the pediatric organ donor with an emphasis on strategies to improve the opportunity for the lungs to be placed in candidates on the transplant list. Pediatr Pulmonol. 2009; 44:536–546. © 2009 Wiley‐Liss, Inc.