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Allergic bronchopulmonary aspergillosis in a 2‐year‐old asthmatic boy with immune dysregulation, polyendocrinopathy, enteropathy, X‐linked
Author(s) -
Ohshima Mihoko,
Futamura Masaki,
Kamachi Yoshiro,
Ito Komei,
Sakamoto Tatsuo
Publication year - 2009
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20992
Subject(s) - immune dysregulation , allergic bronchopulmonary aspergillosis , medicine , enteropathy , immunology , pathogenesis , immune system , immunodeficiency , immunoglobulin e , disease , antibody
Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) is caused by impaired function of CD4 + CD25 + regulatory T cells that play an important role in controlling exaggerated Th2 responses. The pathogenesis of allergic bronchopulmonary aspergillosis (ABPA) appears to be closely associated with the Th2 response. We report the first case of ABPA in a 2‐year‐old asthmatic boy with IPEX, this being an unusually young age for the development of ABPA. Pediatr Pulmonol. 2009; 44:297–299. © 2009 Wiley‐Liss, Inc.