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Strategic plan for pediatric respiratory diseases research: An NHLBI working group report
Author(s) -
Abman Steve,
Jobe Alan,
Chernick Victor,
Blaisdell Carol,
Castro Mario,
Ramirez Maria I.,
Gern James E.,
Cutting Garry,
Redding Greg,
Hagood James S.,
Whitsett Jeffrey,
Abman Steve,
Raj J. Usha,
Barst Robyn,
Kato Gregory J.,
Gozal David,
Haddad Gabriel G.,
Prabhakar Nanduri R.,
Gauda Estelle,
Martinez Fernando D.,
Tepper Robert,
Wood Robert E.,
Accurso Frank,
Teague W. Gerald,
Venegas Jose,
Cole F. Sessions,
Wright Rosalind J.
Publication year - 2009
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20973
Subject(s) - medicine , intensive care medicine , translational research , lung , asthma , pathology , immunology
The Division of Lung Diseases of the National Heart, Lung and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient‐oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease (PVD); sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases, (2) injury, regeneration, and repair in the developing lung, (3) PVD in children, (4) development and adaptation of ventilatory responses to postnatal life, (5) nonatopic wheezing: aberrant large airway development or injury? (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases, and (7) predictive and personalized medicine for children. Pediatr Pulmonol. 2009; 44:2–13. © 2008 Wiley‐Liss, Inc.