Premium
Respiratory impedance and response to salbutamol in healthy Vietnamese children
Author(s) -
Vu Lan T.T.,
Demoulin Bruno,
Nguyen Yen T.,
Nguyen Mai T.H.,
Marchal François
Publication year - 2008
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20904
Subject(s) - salbutamol , medicine , confidence interval , bronchodilator , asthma , relative risk , airway obstruction , anesthesia , airway
A high incidence of childhood asthma has been reported in Ha Noi, Viet Nam, indicating a need to document lung function in these children. The degree of airway obstruction and reversibility may be evaluated from the forced oscillation assessment of respiratory resistance to reactance (Rrs, Xrs). Appropriate controls are necessary for a proper interpretation of patients. The aim of the study was to provide reference values on Rrs and Xrs and response to salbutamol in healthy Vietnamese children. One hundred seventy‐five children aged 6–11 year recruited from one public school in Ha Noi were studied. Measurements were obtained at baseline and after 200 µg inhaled salbutamol. Significant correlations were disclosed between Rrs or Xrs and standing height ( P < 0.0001). Salbutamol significantly decreased Rrs (from 7.1 ± 1.9 hPa.sec/L to 6.2 ± 1.8 hPa.sec/L, P < 0.0001) and increased Xrs (from −1.22 ± 0.64 to −0.91 ± 0.61 hPa.sec/L, P < 0.0001). Rrs response to salbutamol lower limit of 95% confidence interval was −38% from baseline Rrs and, Xrs upper limit was +16% from baseline impedance. It is concluded that reference values for respiratory impedance (Zrs) and thresholds for clinically relevant response to bronchodilator are provided in primary school Vietnamese children. A smaller slope for the observed Rrs–body height relationship is suggested with reference to relevant studies in healthy Caucasians. Pediatr Pulmonol. 2008; 43:1013–1019. © 2008 Wiley‐Liss, Inc.