Premium
A combination therapy of whole lung lavage and GM‐CSF inhalation in pulmonary alveolar proteinosis
Author(s) -
Yamamoto Hajime,
Yamaguchi Etsuro,
Agata Hiroatsu,
Kandatsu Nobuhisa,
Komatsu Toru,
Kawai Seiko,
Baba Kenji,
Awaya Tomonari,
Nishikomori Ryuta,
Tsurusawa Masahito,
Nakata Koh
Publication year - 2008
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20856
Subject(s) - medicine , pulmonary alveolar proteinosis , inhalation , granulocyte macrophage colony stimulating factor , lung , respiratory system , refractory (planetary science) , alveolar macrophage , respiratory disease , bronchoalveolar lavage , pathology , anesthesia , immunology , macrophage , cytokine , biochemistry , chemistry , physics , astrobiology , in vitro
Systemic and inhalation therapy of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is usually effective in controlling autoimmune pulmonary alveolar proteinosis (PAP), but some cases are refractory to GM‐CSF therapy and subjected to whole lung lavage (WLL). A 9‐year‐old girl developed severe respiratory failure due to autoimmune PAP was treated with inhalational 250 µg of GM‐CSF daily, however, it was ineffective. Unilateral WLL was performed three times and subsequent GM‐CSF inhalation therapy yielded marked physiological and radiological improvement and was continued for 1 year. Pediatr Pulmonol. 2008; 43:828–830. © 2008 Wiley‐Liss, Inc.