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IL‐10 gene polymorphism at −1082 A/G is associated with severe rhinovirus bronchiolitis in infants
Author(s) -
Helminen Merja,
Nuolivirta Kirsi,
Virta Miia,
Halkosalo Anne,
Korppi Matti,
Vesikari Timo,
Hurme Mikko
Publication year - 2008
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20793
Subject(s) - bronchiolitis , rhinovirus , medicine , virus , immunology , respiratory disease , allele , respiratory system , pneumovirus , virology , viral disease , gene , paramyxoviridae , lung , biology , genetics
We analyzed polymorphisms of IL‐10 −1082 G/A, IL‐18 −137 G/C, TLR4 +896 A/G, and IFNG +874 T/A in 139 infants under 6 months of age hospitalized with bronchiolitis and 400 unselected blood donors. Causative viruses were determined by PCR. Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL‐10 −1082 allele G non‐carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). Infants with RSV bronchiolitis did not differ from controls. This finding suggests a different pathogenic mechanism for RSV bronchiolitis as compared with wheezing associated with other viral infections, for example, rhinovirus in infants under 6 months of age. Pediatr Pulmonol. 2008; 43:391–395. © 2008 Wiley‐Liss, Inc.