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Risk factors for sleep‐related hypoxia in primary school children
Author(s) -
Urschitz Michael S.,
Eitner Steffen,
Wolff Judith,
Guenther Anke,
UrschitzDuprat Pilar M.,
Schlaud Martin,
Poets Christian F.
Publication year - 2007
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20658
Subject(s) - medicine , overweight , body mass index , odds ratio , population , hypoxia (environmental) , pediatrics , oxygen , environmental health , chemistry , organic chemistry
Sleep‐related hypoxia has adverse effects on cognition in children. Knowledge of factors contributing to sleep‐related hypoxia is sparse. We aimed to identify demographic and clinical factors associated with mild (nadir arterial oxygen saturation 91–93%), moderate (nadir arterial oxygen saturation ≤90%), and recurrent (oxygen desaturation index > 3.9) sleep‐related hypoxia in children. Parental questionnaires were distributed and overnight recordings of arterial oxygen saturation performed in a population‐based cross‐section of primary school children (n = 995). Associations were determined using unconditional logistic regression as well as unadjusted and adjusted odds ratios (OR), and their 95% confidence intervals (95% CI) calculated. Male sex, overweight (i.e., body mass index ≥ 75th percentile), household smoking, symptoms of sleep‐disordered breathing, a current respiratory tract infection, and histories of asthma and respiratory allergy were all significantly associated with sleep‐related hypoxia. In multiple regression analysis, (i) overweight (OR, 95% CI: 2.7, 1.7–4.3) and a history of respiratory allergy (1.7, 1.1–2.7) were independent risk factors for mild sleep‐related hypoxia, (ii) overweight (3.2, 1.7–5.8), a history of respiratory allergy (2.4, 1.4–4.4), and household smoking >10 cigarettes/day (1.8, 1.1–2.8) were independent risk factors for moderate sleep‐related hypoxia, and (iii) overweight (2.3, 1.04–5.3), a history of respiratory allergy (2.5, 1.2–5.1), and a current respiratory tract infection (4.4, 2.0–9.8), were independent risk factors for recurrent sleep‐related hypoxia. Our data suggest that overweight, passive smoking, respiratory allergies, and acute lung disease may independently contribute to sleep‐related hypoxia in children. Pediatr Pulmonol. 2007; 42:805–812. © 2007 Wiley‐Liss, Inc.

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