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Impact of human metapneumovirus and respiratory syncytial virus co‐infection in severe bronchiolitis
Author(s) -
McNamara Paul S.,
Flanagan Brian F.,
Smyth Rosalind L.,
Hart C. Anthony
Publication year - 2007
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20649
Subject(s) - human metapneumovirus , bronchiolitis , medicine , virus , paramyxoviridae , metapneumovirus , mononegavirales , respiratory system , pneumovirinae , virology , immunology , pneumovirus , pneumonia , viral disease , respiratory tract infections
We have previously shown high rates of co‐infection with Respiratory Syncytial Virus (RSV) and human Metapneumovirus (hMPV) in infants with severe bronchiolitis at our institution in 2000–2002, and that co‐infection was associated with increased disease severity. In this study, we have attempted to identify differences in intubated infants with severe RSV infection with and without hMPV co‐infection. Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV− infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable. Pediatr Pulmonol. 2007; 42:740–743. © 2007 Wiley‐Liss, Inc.