Premium
Factors that correlate with sleep oxygenation in children with cystic fibrosis
Author(s) -
Uyan Z.S.,
Özdemir N.,
Ersu R.,
Akpınar İ.,
Keskin S.,
Çakır E.,
Karadağ B.,
Karakoç F.,
Dağlı E.
Publication year - 2007
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20643
Subject(s) - medicine , cystic fibrosis , hypoxemia , pulse oximetry , pulmonary function testing , nocturnal , gastroenterology , lung volumes , oxygenation , lung , oxygen saturation , respiratory disease , anesthesia , oxygen , chemistry , organic chemistry
Objective Cystic fibrosis (CF) patients may develop hypoxemia during sleep. Limited information is available on nocturnal oxygen saturation in CF children with less severe lung disease. The aim of this study was to investigate the degree of nocturnal oxygen desaturation and factors that correlate with nocturnal oxygenation in CF children with normal pulmonary function tests (PFTs) or mild to moderate lung disease. Method Awake resting and post‐exercise SpO 2 were measured by pulse oximetry. Each patient had overnight oximetry monitorization at home. Six minutes walk test (6MWT), Shwachman–Kulczycki (S–K), Brasfield and computed tomography (CT) scores, blood gas analysis and nutritional status of patients were evaluated. Results Twenty‐four patients with a median age of 9.5 years were included. Nocturnal mean SpO 2 did not differ according to the severity of lung disease based on PFT. However, lowest SpO 2 obtained was lower in children with both mild and moderate lung disease compared to normals (87.4% vs. 91.7%, respectively, p = 0.009). 95.8% of CF children with normal PFT or mild to moderate lung disease had desaturation events during sleep. Nocturnal mean SpO 2 correlated with S–K (Spearman's rho = 0.64, p < 0.0001), Brasfield (Spearman's rho = 0.31, p = 0.007) and CT scores (Spearman's rho = −0.67, p < 0.0001) as well as PaO 2 (Spearman's rho = 0.28, p = 0.021), SaO 2 (Spearman's rho=0.28, p = 0.023), z‐score of weight (Spearman's rho = 0.23, p = 0.20) and height (Spearman's rho = 0.20, p = 0.30), there was no correlation with 6MWT. Conclusions In CF children with normal PFT or mild‐to‐moderate lung disease, nocturnal oxygenation may correlate with S–K, Brasfield and CT scores as well as PaO 2 , SaO 2 , z‐score of weight and height. Pediatr Pulmonol. 2007; 42:716–722. © 2007 Wiley‐Liss, Inc.