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Association between inflammatory markers in induced sputum and clinical characteristics in children with non‐cystic fibrosis bronchiectasis
Author(s) -
Guran Tulay,
Ersu Refika,
Karadag Bulent,
Nuri Akpinar Ihsan,
Yanikkaya Demirel Gulderen,
Hekim Nezih,
Dagli Elif
Publication year - 2007
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20587
Subject(s) - medicine , sputum , bronchiectasis , interquartile range , spirometry , cystic fibrosis , gastroenterology , pulmonary function testing , high resolution computed tomography , pathology , lung , asthma , tuberculosis
To study clinical, radiological and laboratory features of children with non‐cystic fibrosis (non‐CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high‐resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty‐seven children with steady‐state non‐CF BE were cross‐sectionally evaluated by symptom scores, pulmonary function tests, anatomic extension and severity scores of BE in HRCT and tumor necrosis factor‐alpha (TNF‐α) and interleukin‐8 (IL‐8) levels in induced sputum. There were 16 girls and 11 boys. Median (interquartile range) age of study group was 11.4 (9.5–13.6) years, follow‐up duration was 3.5 (2–6.5) years and symptom scores were 4 (3–6). Pulmonary function tests revealed FEV 1 of 82%pred (72–93), FVC of 82%pred (74–92), and FEF 25–75% of 82%pred (68–95). According to anatomic extent of BE on HRCT; 2 patients had mild, 4 had moderate and 21 had severe BE. Based on severity scores of HRCT; 10 patients had mild, 10 had moderate and 7 had severe BE. Neutrophils consisted 29.9% (14.9–53.7) of the total leucocytes in induced sputum samples. Sputum concentration of TNF‐α was 58 pg/ml (9.2–302) while IL‐8 concentration was 2.7 ng/ml (1.7–2.8). Symptom scores correlated with FEV 1 and sputum IL‐8 levels (r = −0.49, r = 0.67, P < 0.05). There was a significant correlation between HRCT severity scores and symptoms, FEV 1 , sputum IL‐8 and TNF‐α levels (r = 0.64, r = −0.68, r = 0.41, r = 0.41, respectively, P < 0.05). In children BE is associated with ongoing inflammation. This inflammation can be reliably monitored by radiological scores, spirometry, as well as sputum inflammatory markers. Follow‐up of children with BE using these clinical tools may improve patient care. Pediatr Pulmonol. 2007; 42:362–369. © 2007 Wiley‐Liss, Inc.