Premium
Lung function and exhaled nitric oxide levels in infants developing chronic lung disease
Author(s) -
Williams Olivia,
Dimitriou Gabriel,
Hannam Simon,
Rafferty Gerrard F.,
Greenough Anne
Publication year - 2007
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20475
Subject(s) - medicine , gestational age , exhaled nitric oxide , functional residual capacity , cohort , respiratory disease , gestation , pediatrics , bronchopulmonary dysplasia , lung , intensive care , receiver operating characteristic , lung disease , lung function , lung volumes , pregnancy , intensive care medicine , genetics , biology
Abstract Chronic lung disease (CLD) is a common outcome of neonatal intensive care. To determine whether the results of serial exhaled nitric oxide (eNO) measurements during the perinatal period differed between infants who did and did not develop CLD. In addition, we wished to assess whether eNO results were more predictive of CLD development than lung function test results or readily available clinical data (gestational age and birthweight). The patients were 24 infants with a median gestational age of 27 (range 25–31) weeks. Measurements of eNO levels, functional residual capacity (FRC), and compliance of the respiratory system (CRS) were attempted on postnatal days 1, 3, 5, 7, 14, and 28 days. The 12 infants who developed CLD were of significantly lower birthweight and gestational age than the rest of the cohort; in addition, they had lower median FRC ( P < 0.02) and CRS ( P < 0.02) results, but not higher eNO levels, in the first week after birth. Construction of receiver operator characteristic (ROC) curves demonstrated that the CRS and FRC results on Day 3 were the best predictors of CLD development; the areas under the ROC curves were 0.94 and 0.91, respectively. Early lung function test results, but not eNO levels, are useful in predicting CLD development, but are not significantly better than birthweight. Pediatr Pulmonol. 2007; 42:107–113. © 2006 Wiley‐Liss, Inc.