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Epstein‐Barr virus‐associated bronchial leiomyoma in a boy with cellular immunodeficiency
Author(s) -
Hatano Miho,
Takada Hidetoshi,
Nomura Akihiko,
Ohga Shouichi,
Ohshima Koichi,
Saeki Isamu,
Tajiri Tatsuro,
Taguchi Tomoaki,
Suita Sachiyo,
Hara Toshiro
Publication year - 2006
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20375
Subject(s) - medicine , leiomyoma , epstein–barr virus , virus , pathogenesis , respiratory disease , human immunodeficiency virus (hiv) , pathology , immunology , virology , disease , lung
Bronchial leiomyoma is a rare disease in children. Recently, the association of leiomyoma and HIV infection was reported. We describe a boy with a cellular immunodeficiency, who had endobronchial leiomyoma. The tumor cells were positive for Epstein‐Barr virus‐encoded RNA‐1 (EBER‐1) and Epstein‐Barr virus‐determined nuclear antigen‐2, suggesting a role of Epstein‐Barr virus in the pathogenesis of leiomyoma. Pediatr Pulmonol. © 2006 Wiley‐Liss, Inc.