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Obstructive Sleep‐Disordered Breathing and Fasting Insulin Levels in Nonobese Children
Author(s) -
Kaditis Athanasios G.,
Alexopoulos Emmanouel I.,
Damani Eleni,
Karadonta Ioanna,
Kostadima Eleni,
Tsolakidou Alexandra,
Gourgoulianis Konstantinos,
Syrogiannopoulos George A.
Publication year - 2005
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20306
Subject(s) - medicine , sleep disordered breathing , insulin , breathing , endocrinology , sleep (system call) , obstructive sleep apnea , anesthesia , computer science , operating system
Abstract A positive correlation of severity of sleep‐disordered breathing with morning fasting insulin levels, which is independent of obesity, was reported in adults and obese children. We hypothesized that both severity of sleep‐disordered breathing and relative body mass index predict fasting insulin and homeostasis model assessment (HOMA) index values in nonobese children with habitual snoring. One hundred and ten subjects with habitual snoring (median age, 6 years; range, 2–13 years) underwent polysomnography and measurement of morning fasting insulin and glucose levels. The HOMA index was calculated. Thirty children had an apnea‐hypopnea index (AHI) ≥ 5 episodes/hr (median, 7.8 episodes/hr; range, 5–42.3 episodes/hr), and 80 subjects had an AHI < 5 episodes/hr (median, 1.9 episodes/hr; range, 0.2–4.9 episodes/hr). Insulin and HOMA index values were similar in children with AHI ≥ 5 episodes/hr (median insulin, 4.9 mU/l; range, 1.66–19.9 mU/l; and median HOMA, 1; range, 0.36–4.95) and in subjects with AHI < 5 episodes/hr (median insulin, 5.8 mU/l; range, 0.74–41.1 mU/l; and median HOMA, 1.3; range, 0.13–9.72) ( P > 0.05). No significant correlations were identified between insulin or HOMA index values and any polysomnography indices ( P > 0.05). When multiple linear regression was carried out, relative body mass index was a significant predictor of log‐transformed insulin levels or HOMA index values, but AHI and percentage of sleep time with saturation <95% were not. In conclusion, contrary to findings in adults and in obese children, severity of sleep‐disordered breathing is not a significant predictor of fasting insulin or HOMA index values in nonobese children with habitual snoring. Pediatr Pulmonol. © 2005 Wiley‐Liss, Inc.